Dissection of BRCA-mediated Tumor Suppression Pathways

Principal Investigator: Patrick Sung | Affiliation: University of Texas Health Science Center at San Antonio

Research Keywords

DNA repair

Research Questions

• What are the regulators of BRCA function?
• What are BRCA-independent DNA repair pathways?
• What are the DNA repair mechanisms?
• What are the drug vulnerabilities of BRCA deficient cells?"

Specific Aims

• Aim 1:
• Aim 2:
• Aim 3:

Methods

1. Microscopy
2. DNA replication
3. 3D culture
4. Organoids